Liverpool will be aiming to celebrate the birth of their most famous manager Bill Shankly with victory over arch-rivals Manchester United.
Monday marks 100 years since the birth of Shankly and the home fans would see victory over United as the ideal birthday present for the Liverpool legend.
Brendan Rodgers' side go into the game above United in the table after winning their opening two games of the season and they will be looking to set down a marker against the reigning champions.
Rodgers lost both meetings with United last season and breaking his duck against their old foes would be a major boost to their top-four aspirations.
United boss David Moyes has never won at Anfield during his time in charge of Everton and he will be seeking to end that record on Sunday.
United have won their last three league meetings against Liverpool 2-1, with Robin van Persie scoring in both fixtures last season.
Andre Marriner is the man in the middle for what should be as usual a passionate, fiery encounter between England's two most successful club sides.
Jose Mourinho went to Old Trafford on Monday night and shut up shop, making sure Chelsea didn't get beat. He put the pressure on Man United and they didn't do enough. This is now a big game for David Moyes because if they lose to Liverpool a few questions will be asked. They've had a tough start and if they go unbeaten in the first three games, I think that will be positive. However, if they lose the game, then that'll be two big games against big rivals that he hasn't won.
Liverpool has a number of injury concerns to contend with before Brendan Rodgers finalises his line-up.
Defensive duo Kolo Toure and Aly Cissokho and midfielder Joe Allen picked up injuries during the midweek Capital One Cup win over Notts County.
If Toure fails to recover from his groin problem, Liverpool is hoping that Martin Sktrel will recover from a knee injury to take his place alongside Daniel Agger in the heart of their defence.
Luis Suarez remains absent for Liverpool as he serves the eighth game of his 10-match ban meaning the in-form Daniel Sturridge will continue to lead the attack.
Sebastian Coates is a long-term absentee for Liverpool as he recovers from a cruciate knee injury.
Wayne Rooney could keep his place in the starting XI after impressing against Chelsea on Monday night.
Phil Jones is expected to shake off a back injury he picked up against Chelsea to start at right-back in place of the injured Rafael.
United boss David Moyes has no other injury concerns to deal with as he prepares for his first experience of Manchester United versus Liverpool at Anfield.