Liverpool visit Trabzonspor looking to protect a slender 1-0 advantage in this Europa League play-off second leg but they will have to do so without influential duo Steven Gerrard and Fernando Torres.
A draw or win will see the Reds qualify for the group stages of the competition although the job becomes decidedly more difficult with both Gerrard and Torres out of contention, as well as a number of other first team members including the likes of Javier Mascherano, Maxi Rodriguez, Milan Jovanovic and Daniel Agger.
It's been something of an uncomfortable start to life in the Anfield hotseat for new boss Roy Hodgson with Liverpool having failed to register a win in their opening two Premier League games that included a dismal 3-0 defeat at the hands of Manchester City.
The Reds are undoubtedly still favourites to progress and avoid the humiliation of a pre-group stage exit after Ryan Babel's solitary strike in the first leg secured victory although, as Hodgson himself confessed, Liverpool still have it all to do having failed to kill off their Turkish opponents last week.
While the Merseyside outfit are stuck on one point in 17th place after two games in England's top flight, Trabzonspor have picked up maximum points in Turkey having won both their opening two league fixtures of the season, including an impressive 3-2 win over rivals Fenerbahce on Monday.
Defeat for Hodgson and his charges resulting in Europa League elimination would be a bitter pill to swallow after all the disappointment associated with Monday's visit to Eastlands although Trabzonspor will certainly fancy their chances of progression given the Reds' somewhat depleted squad.
Having decided to switch things around for Monday's meeting with Fenerbahce, Trabzonspor coach Senol Gunes could be tempted to go with the same starting XI that only narrowly lost out at Anfield in the first leg.
After missing out on a starting spot against the Reds last week, Ibrahima Yattara will be desperate to get the nod having found the net against Fener.
Striker Umut Bulut will be hoping for a recall to the side while Burak Yilmaz will be another looking to be included having not featured on Monday night.
Possible Starting XI: Kivrak; Korkmaz, Glowacki, Gulselam, Cale; Yilmaz, Balci, Inan, Colman; Gutierrez, Bulut.
Roy Hodgson has confirmed that Liverpool will be without both captain Steven Gerarrd and Spanish striker Fernando Torres. England midfielder Gerrard is struggling with a back problem, while Hodgson is reluctant to field Torres for three consecutive games as he continues his recovery from last season's injury problems.
Wantaway Argentina international Javier Mascherano has again been left out of the Reds' squad heading for Turkey, while Daniel Agger (concussion) and Maxi Rodriguez (illness) are also absent.
Forward Milan Jovanovic has also been left out of the travelling party, seemingly being rested after the club's hectic start to the new season.
Possible Starting XI: Reina; Johnson, Carragher, Skrtel, Aurelio; Lucas, Poulsen; Kuyt, Cole, Babel; Ngog.