Tottenham Hotspur will be looking to secure back-to-back home wins and end Liverpool's eight-match unbeaten run on Wednesday.
A 3-1 derby success over West Ham United on Sunday saw Spurs returning to winning ways following three straight defeats, and they will want to build on that result and close back in on the top four.
History would appear to be in Spurs' favour, with the north London outfit having emerged victorious in their last five meetings with Liverpool at White Hart Lane in all competitions.
Bringing an end to that sequence of results will be Brendan Rodgers' top priority, with Liverpool heading to the capital still searching for a spark to ignite their season.
The Reds have become hard to beat, which is a step in the right direction, but seven draws in 13 games this season have held them back.
It is, however, worth noting that only reigning champions Manchester City have gone longer without tasting a Premier League defeat than the men from Merseyside and Rodgers will feel that his side can kick on once momentum is established.
Emmanuel Adebayor will serve the second game of his three-match ban in midweek, meaning Jermain Defoe will get the opportunity to lead the Tottenham lead once more.
Mousa Dembele, who returned from injury to make a 10-minute cameo appearance against West Ham, may be returned to Andre Villas-Boas' starting XI, but the Portuguese tactician is not expected to make too many changes to a winning team.
Scott Parker is back in light training following an Achilles injury, but is some way short of full match fitness, while Benoit Assou-Ekotto (knee) and Younes Kaboul (knee) remain on the sidelines.
Midfielder Sandro has been passed fit after being carried off on a stretcher with a stomach injury against West Ham.
Andre Wisdom has recovered from the knee injury which kept him out of a goalless draw with Swansea at the weekend and returns to the Liverpool squad.
If the teenager regains his place in the back four, winger Stewart Downing - who played at left-back at the Liberty Stadium on Sunday - would be the player most likely to make way.
Midfielder Lucas Leiva, who played an hour for the reserves on Friday, will not be included but could come into contention at the weekend.