Liverpool and Arsenal on Sunday lunchtime meet at Anfield when both clubs will be looking for their first Premier League wins of the season and Nuri Sahin could make his debut.
Neither side have yet to collect a three-point haul in the wake of eventful summers, which have set both clubs into new eras.
Hosts Liverpool have undergone vast change following the arrival of Brendan Rodgers and their new boss will be keen for a Premier League win after the defeat by West Bromwich Albion and last Sunday's draw with Manchester City.
Meanwhile, a Robin van Persie-less Arsenal, who have also sold Alex Song while Theo Walcott's future was thrown into doubt before the transfer deadline, have yet to score in the top flight since parting with their former captain after stalemates with Sunderland and Stoke City.
Both clubs will therefore be determined to win on Merseyside in a game which can be seen live on Sky Sports HD 1 and it promises to be another engrossing encounter between two of the game's heavyweights.
The potential Liverpool debut of Sahin, who almost joined Arsenal on loan from Real Madrid before instead switching to Anfield, is an added element for this weekend's match amid all the hype regarding the midfielder.
Last season's correlating fixture in March saw Arsenal come from a goal down against the run of play to stun Liverpool with a superb injury-time, volleyed winner from Van Persie.
The Merseysiders' league season subsequently unravelled, costing Kenny Dalglish his job, and remaining players will be keen to settle the score.
Liverpool defender Daniel Agger is available for Sunday's Premier League clash against Arsenal after serving a domestic suspension.
Sebastian Coates replaced the Dane in last week's draw with Manchester City.
Brazilian midfielder Lucas has been ruled out for two to three months with a thigh injury but Rodgers otherwise has a fully-fit squad.
Arsenal defender Laurent Koscielny returns to the squad for Sunday's Premier League clash with Liverpool.
Koscielny has recovered from a calf injury, but goalkeeper Wojciech Szczesny faces a fitness test on his rib problem.
Midfielder Jack Wilshere (ankle) and defender Bacary Sagna (broken leg) continue their rehabilitation.