Rafael Benitez has finally got something to smile about after watching Liverpool beat Manchester United for the first time in his Anfield career thanks to an own goal from Wes Brown and Ryan Babel's winner.
The Liverpool boss had never beaten United in eight previous league games, with the champions having won the last five meetings between these two giants.
But United wilted under a relentless second-half pressure, had Nemanja Vidic sent-off and saw substitute Babel secure victory.
Carlos Tevez put United ahead early on. But after a torrid opening period, Liverpool were level with a Wes Brown own goal before Liverpool dominated the second half and grabbed a priceless win with 13 minutes left.
Liverpool gave new signing Albert Riera his debut but Steven Gerrard and Fernando Torres were not risked any closer to the initial action than the bench.
For the champions, Michael Carrick returned after an ankle problem, but all eyes were on £30million striker Dimitar Berbatov on his first appearance for his new club.
Liverpool fans staged a march to the ground from a local pub to protest at the club's American owners.
But that did not stop co-owner George Gillett taking his place in the directors' box, although not in the front row close to the fans.
There was also a row of smartly-suited Americans, all singing along to "You'll never walk alone" - the anthem moved to seconds before kick-off rather than when the teams march out, presumably to unsettle United.
It did not work. The champions were ahead after just three minutes.
Berbatov was allowed to get to the line by some sloppy marking and covering, and Liverpool's defence was nowhere to be seen when his pulled back cross was lashed home by Tevez.
United were quicker and more mobile all over the pitch while Liverpool continually conceded possession.
But the Merseysiders should have scored after 13 minutes when Edwin van der Sar fumbled a corner and Kuyt's blast from three yards hit Paul Scholes on the line.
Liverpool at last started to get into the match as Tevez was booked for a foul on Alvaro Arbeloa and a succession of free-kicks pinned United back.
And they were level after 26 minutes. Xabi Alonso's curling, low shot into the area deflected off Patrice Evra and Van der Sar hurled himself forward.
But he only managed to push the ball on to Brown, who could do nothing about it cannoning off him and over the line. Riera followed the ball in, but it was the United man's last touch.
United sent on Ryan Giggs for Carrick at the break, the midfielder having taken a heavy blow on his ankle in the first half.
Liverpool started the second period in much sharper form, Benayoun almost saw a flicked effort evade Van der Sar and Alonso fired over from 20 yards.
Keane narrowly missed breaking his scoring duck when he failed by inches to connect with a Javier Mascherano cross-shot. United's reply came from Paul Scholes who drove wide.
United sent on Hargreaves for Scholes after 66 minutes, having been forced back for much of the second spell.
Two minutes later Liverpool introduced Gerrard in place of Benayoun as United started to come back into the game.
As if to underline the point, Jose Reina was forced into a fine save from a dipping Giggs volley.
Riera was taken off after 71 minutes and replaced by Babel having made a good impression after a shaky start.
And on 77 minutes, Liverpool's pressure paid off. Mascherano battled his way down the right and to the line, Kuyt took up possession and played the ball across for Babel to crack home.
Nani came on for Anderson, and Rio Ferdinand was booked for bringing down Keane as the Irishman looked to be bursting through on goal. Nani was next into the book for bringing down Mascherano.
Liverpool were going to replace Keane with David Ngog, but changed their minds at the last moment when it was clear Mascherano had injured his ankle. The Argentinian limped off and Sami Hyypia came on instead.
United had Nemanja Vidic pushed up front by now, and Liverpool needed three central defenders.
Vidic was then sent off for crashing his arm into Alonso's face after 89 minutes, a second yellow card swiftly followed by a red. He will now miss the visit to Chelsea on September 21.
The Liverpool boss had never beaten United in eight previous league games, with the champions having won the last five meetings between these two giants.
But United wilted under a relentless second-half pressure, had Nemanja Vidic sent-off and saw substitute Babel secure victory.
Carlos Tevez put United ahead early on. But after a torrid opening period, Liverpool were level with a Wes Brown own goal before Liverpool dominated the second half and grabbed a priceless win with 13 minutes left.
Liverpool gave new signing Albert Riera his debut but Steven Gerrard and Fernando Torres were not risked any closer to the initial action than the bench.
For the champions, Michael Carrick returned after an ankle problem, but all eyes were on £30million striker Dimitar Berbatov on his first appearance for his new club.
Liverpool fans staged a march to the ground from a local pub to protest at the club's American owners.
But that did not stop co-owner George Gillett taking his place in the directors' box, although not in the front row close to the fans.
There was also a row of smartly-suited Americans, all singing along to "You'll never walk alone" - the anthem moved to seconds before kick-off rather than when the teams march out, presumably to unsettle United.
It did not work. The champions were ahead after just three minutes.
Berbatov was allowed to get to the line by some sloppy marking and covering, and Liverpool's defence was nowhere to be seen when his pulled back cross was lashed home by Tevez.
United were quicker and more mobile all over the pitch while Liverpool continually conceded possession.
But the Merseysiders should have scored after 13 minutes when Edwin van der Sar fumbled a corner and Kuyt's blast from three yards hit Paul Scholes on the line.
Liverpool at last started to get into the match as Tevez was booked for a foul on Alvaro Arbeloa and a succession of free-kicks pinned United back.
And they were level after 26 minutes. Xabi Alonso's curling, low shot into the area deflected off Patrice Evra and Van der Sar hurled himself forward.
But he only managed to push the ball on to Brown, who could do nothing about it cannoning off him and over the line. Riera followed the ball in, but it was the United man's last touch.
United sent on Ryan Giggs for Carrick at the break, the midfielder having taken a heavy blow on his ankle in the first half.
Liverpool started the second period in much sharper form, Benayoun almost saw a flicked effort evade Van der Sar and Alonso fired over from 20 yards.
Keane narrowly missed breaking his scoring duck when he failed by inches to connect with a Javier Mascherano cross-shot. United's reply came from Paul Scholes who drove wide.
United sent on Hargreaves for Scholes after 66 minutes, having been forced back for much of the second spell.
Two minutes later Liverpool introduced Gerrard in place of Benayoun as United started to come back into the game.
As if to underline the point, Jose Reina was forced into a fine save from a dipping Giggs volley.
Riera was taken off after 71 minutes and replaced by Babel having made a good impression after a shaky start.
And on 77 minutes, Liverpool's pressure paid off. Mascherano battled his way down the right and to the line, Kuyt took up possession and played the ball across for Babel to crack home.
Nani came on for Anderson, and Rio Ferdinand was booked for bringing down Keane as the Irishman looked to be bursting through on goal. Nani was next into the book for bringing down Mascherano.
Liverpool were going to replace Keane with David Ngog, but changed their minds at the last moment when it was clear Mascherano had injured his ankle. The Argentinian limped off and Sami Hyypia came on instead.
United had Nemanja Vidic pushed up front by now, and Liverpool needed three central defenders.
Vidic was then sent off for crashing his arm into Alonso's face after 89 minutes, a second yellow card swiftly followed by a red. He will now miss the visit to Chelsea on September 21.